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• Mark Akeson (BME) Control and Analysis of DNA and RNA Using Nanoscale Pores
• Dave Deamer (BME) Biophysics of Membranes and Single Molecules
• Rebecca DuBois (BME) Structure, Function, and Engineering of Virus Proteins
• Mike Isaacson (EE) Nano- and Microfabrication Technology for Biomedical and Diagnostic devices
• Joel Kubby (EE) Applications of Adaptive Optics for Biological Microscopy
• Scott Oliver (Chem) Cationic Materials for Trapping of Heavy Metal Pollutants
• Nader Pourmand (BME) Single Cell Analysis and Manipulation, Biosensor, Nanotechnology, DNA Sequencing
• Holger Schmidt, (EE) Integrated Optofluidics: Detecting and Analyzing Single Molecules on a Chip
• Ali Yanik (EE) Development of Nano-fluidic Platforms for Cancer Diagnostics
• Jin Zhang (Chemistry) The Application of Molecular and Nanomaterial Systems to the Detection and Treatment of Cancer

Prof Mark AkesonControl and Analysis of DNA and RNA Using Nanoscale Pores

Mark Akeson, Biomolecular Engineering

Mark Akeson's research is focused on the use of nanopore detectors - instruments built around a tiny pore in a membrane or thin, solid-state wafer. These pores are just big enough to allow a single strand of DNA to pass through. Akeson and his collegues use the detectors to understand the dynamics and structure of DNA duplex ends, including those of retrotransposons and HIV. Akeson also investigates the coupling of processive DNA-modifying enzymes to nanopores, both protein and solid-state. Together with UCSC Professors William Dunbar and David Deamer, he has demonstrated enzymatic control of single DNA in nanopores with sequence specificity and real-time feedback control. [MORE]

Akeson Publications
Mark Akeson's Email

Prof DeamerNanopore Methods of DNA Analysis

David Deamer, Biomolecular Engineering

Professor David Deamer and his collaborators have developed a nanopore device that captures single nucleic acid molecules and analyzes their structure, dynamic motion and base sequences. [More]

Deamer's Publications Dave Deamer's E-Mail


Prof DuBoisStructure, Function, and Engineering of Virus Proteins

Rebecca DuBois, Biomolecular Engineering

Professor DuBois is a structural biologist studying viral surface and replication proteins. She uses her discoveries to design novel vaccines, to develop nanoscale drug delivery vehicles, and to develop antiviral therapeutics. [More]

DuBois Publications Rebecca Dubois' E-Mail


Prof XXNano- and Microfabrication Technology for Biomedical and Diagnostic devices

Mike Isaacson, Dept. of Electrical Engineering

Michael Isaacson's research group uses technology developed by the semiconductor industry to study biological systems and develop biomedical devices. The work involves fabrication techniques and imaging tools for making and visualizing devices and structures on the nanoscale. For example, the group has developed microelectronic devices that can be implanted into insect brains to record signals from the brain's neural circuits. Interestingly, information about how the neural circuits work can then be used to further improve microelectronic devices. [More]

  Mike Isaacson's Email


Prof Joel KubbyApplications of Adaptive Optics for Biological Microscopy

Joel Kubby, Dept. of Electrical Engineering

Professor Joel Kubby is collaborating with engineers, physicists and biologists to utilize Adaptive Optics for the improvement of deep tissue imaging of living cells. Current biological microscopy is incapable of obtaining high quality live imaging in samples greater than 30 microns beneath the plasma membrane, where many critical cellular processes occur. Much of the degradation in image quality is the result of local differences in the refractive index, both within the sample and between the sample and the immersion lens. Adaptive optics was first used to correct for image aberrations in astronomical imaging. Kubby and his collaborators have shown that the same principles that improved resolution in telescopes can be adapted to improve wide-field, confocal, two-photon, super-resolution and spinning disk microscopy systems that are crucial for biological research. [More]
Kubby Publications Joel Kubby's Email

Prof Scott OliverCationic Materials for Trapping of Heavy Metal Pollutants

Scott Oliver Dept. of Chemistry and Biochemistry

The Oliver group focuses on creating new cationic materials that will uptake EPA priority pollutants such as perchlorate and chromate. These materials release benign anions while soaking up heavy metals, which exist in water as their oxo-anions. The group has discovered a new class of extended inorganic and metal-organic hosts and investigates their anion exchange properties. The goal is the selective uptake of anions such as perchlorate, pertechnetate and chromate with high selectivity and potential reusability. Recent breakthroughs have led to materials that show record uptake in grams per grams for permanganate and perrhenate, studied as surrogates for the problematic pertechnetate. The materials outperform anion exchange resins and the cationic clay known as hydrotalcite by several-fold, even when non-toxic anions were added in over 100-fold excess concentration. [More]

Oliver Publications Scott Oliver's Email

Prof Nader PourmandSingle Cell Analysis and Manipulation, Biosensor, Nanotechnology, DNA Sequencing

Nader Pourmand, Dept. of Biomolucular Engineering

The Pourmand lab develops new tools and technologies that integrate biology, electronics, and nanofabrication for the detection and study of genes and proteins. These tools are specifically designed to increase the speed and lower the cost of sample analysis. The lab directs particular attention to the development of medically relevant technology, such as instruments for single cell analysis. Pourmand is also Director of Genome Technology Center. [More]

Pourmand Publications Pourmand's Email

Prof Holger SchmidtIntegrated Optofluidics: Detecting and Analyzing Single Molecules on a Chip

Holger Schmidt, Dept. of Electrical Engineering

Optofluidics describes the combination of optics and microfluidics and holds great promise for novel devices for biomedical instrumentation, analytical chemistry and other fields that deal with liquid analytes. A highly desirable extension of optofluidics is to use integrated optics to replace the bulky microscopy analysis that is still commonly in use. This would allow development of a fully planar, fully integrated lab on a chip. We are using optofluidic approaches for early infectious disease and cancer detection and genome analysis. [More]

Schmidt Publications Holger Schmidt's Email

Prof Alli YanikDevelopment of Nano-fluidic Platforms for Cancer Diagnostics

Ali Yanik, Dept. of Electrical Engineering

Ali Yanik's current research focuses on Circulating Tumor Cell (CTC) detection from human blood, using nano-fluidic platforms for cancer diagnostics. His research interests includes nanoplasmonic and metamaterial devices for ultrasensitive infrared/terahertz spectroscopy of biomolecules/chemicals and high-throughput, cost-effective BioNEMS technologies for life sciences and point-of-care diagnostics. His expertise is in high-end nanolithography and bio-patterning as well as theory and engineering of nanophotonic devices. [More]

Yanik Publications Ali Yanik's Email

Prof Jin ZhangThe Application of Molecular and Nanomaterial Systems to the Detection and Treatment of Cancer

Jin Zhang , Dept. of Chemistry and Biochemistry

The Zhang research group is interested in the application of molecular and nanomaterial systems in conjunction with optical spectroscopy and related techniques for biomedical detection and treatment, with emphasis on cancer therapies and cancer biomarker detection.  Specific projects include: 1) investigation of mechanisms of photodynamic therapy and catalytic therapy based on porphyrins, phthalocyanines, and related compounds; 2) detection of small molecule, protein, and DNA cancer biomarkers using fluorescence based on quantum dots (QDs) and surface-enhanced Raman scattering (SERS) based on metal nanostrutcures; and 3) photothermal imaging and therapy of cancer using unique metal nanostructures.  This research involves systematic study of the structural, optical, and photophysical as well as photochemical properties of the materials using a combination of microscopy, x-ray, spectroscopy, and electrochemistry techniques. [More]
Zhang Publications Jin Zhang's Email

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