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Small Molecule Drug Discovery and Vaccine Development

• Victoria Auerbuch Stone (METX) Interplay between bacterial pathogens and the mammalian innate immune system
• Phil Berman (BME) Biotechnology and Infectious Diseases
• Phil Crews (Chem) Marine Natural Products as Potent Agents Against Human Disease
• Rebecca DuBois (BME) Structure, Function, and Engineering of Virus Proteins
• Ted Holman (Chem) Lipoxygenase Inhibitors as Potential Anti-Inflammatory Drugs
• Scott Lokey (Chem) A Small Molecule Approach for Studying Signaling Pathways Related to Cell Motility and Cancer
• Carrie Partch (Chem) Exploring the Molecular Basis for Circadian Timekeeping in Mammals
• Seth Rubin (Chem) Molecular Mechanisms of Cell Cycle Regulation and Cancer
• Josh Stuart (BME) Computational Functional Genomics, with Application to Integrative Analysis of Cancer
• Christopher Vollmers (BME) Development of DNA Sequencing Tools for the Analysis of B cells
• Fitnat Yildiz (METX) Ex-vivo Survival Mechanisms Used by Vibrio cholerae between Epidemics

Prof Victoria Auerbuch StoneInterplay between bacterial pathogens and the mammalian innate immune system

Victoria Auerbuch Stone , Microbiology and Environmental Toxicology

Professor Auerbuch Stone’s research interests focus on how mammalian cells recognize and respond to bacterial pathogens and how, in turn, bacterial pathogens manipulate the mammalian innate immune system. We use human pathogenic Yersinia to study the type III secretion system (T3SS), a needle-like apparatus used by dozens of pathogens, including the gut microbe Y. pseudotuberculosis and the plague agent Y. pestis, to inject effector proteins inside mammalian target cells. The T3SS is an evolutionarily ancient structure that is recognized by several mammalian innate immune receptors, leading to a host response presumably aimed at eliminating the invading pathogen. Current research in Professor Auerbuch Stone’s lab focuses on gaining a better understanding of how Yersinia regulate their T3SS, on probing the mammalian innate immune response to the Yersinia T3SS, and on discovery and characterization of small molecule inhibitors of the T3SS. [More]
Auerbuch Stone Publications Auerbuch Stone's Email

Prof XXXBiotechnology and Infectious Diseases

Phil Berman, Dept. of Biomolecular Engineering

Professor Berman is a pioneer in the development of recombinant vaccines for AIDS and other infectious diseases. His research interests include the development of vaccines, therapeutics, and diagnostics for the prevention and treatment of infectious diseases, as well as the development of new technology for commercial production of complex recombinent glycoproteins. [More]

Berman Publications Phil Berman's Email

Prof Phil CrewsMarine Natural Products as Potent Agents Against Human Disease

Phil Crews, Dept. of Chemistry and Biochemistry

A primary goal of Phillip Crews' marine natural products research is to understand the chemistry of tropical marine sponges. Using bioassay-guided isolation assists us in the discovery of natural products potent against human diseases, such as cancer or viruses. Their search for novel active compounds incorporates elements of structure elucidation, but there are other dimensions to this research, including questions in the areas of chemical ecology, marine natural products biosynthesis, and the relationship between secondary metabolite chemistry and taxonomy... [More]

Crews' Publications Phil Crews' E-Mail

Prof DuBoisStructure, Function, and Engineering of Virus Proteins

Rebecca DuBois, Biomolecular Engineering

Professor DuBois is a structural biologist studying viral surface and replication proteins. She uses her discoveries to design novel vaccines, to develop nanoscale drug delivery vehicles, and to develop antiviral therapeutics. [More]

DuBois Publications Rebecca Dubois' E-Mail


Prof HolmanLipoxygenase Inhibitors as Potential Anti-Inflammatory Drugs

Ted Holman, Dept. of Chemistry & Biochemistry

Lipoxygenases are enzymes implicated in a broad range of inflammatory diseases, such as diabetes, heart disease, and stroke, to name a few. Ted Holman's laboratory examines the enzymatic mechanism and biological function of lipoxygenase in the hopes of understanding how the enzyme functions and developing novel inhibitors. In collaboration with medical school collaborators, his laboratory has identified potent lipoxygenase inhibitors and are currently characterizing their structure/function reactivity. The results of this work will shed light on their potential as anti-inflammatory agents. [More]

Holman's Publications Ted Holman's E-Mail

Prof Scott LokeyA Small Molecule Approach for Studying Signaling Pathways Related to Cell Motility and Cancer

Scott Lokey, Chemistry and Biochemistry

The laboratory of Scott Lokey uses a small molecule approach, called chemical genetics, to study signaling pathways related to cell cycle checkpoints and the actin cytoskeleton. In one study, Lokey and his co-workers are developing screens of natural compounds that can be used to examine how cells detect their own DNA damage. Studies such as these might lead to development of a new class of chemotherapeutic agents. [More]

Lokey Publications Lokey's E-Mail

Prof Rubin Exploring the Molecular Basis for Circadian Timekeeping in Mammals

Carrie Partch , Chemistry and Biochemistry

Mammalian physiology is synchronized into 24-hour rhythms that coincide with the solar day by an intrinsic molecular clock. As a global regulator of homeostasis, disruption of the circadian clock has profound consequences on human health, leading to depression, metabolic syndromes, cancer, and premature aging. The Partch lab studies how the 24-hour periodicity of this molecular clock is generated and how it integrates with the cell cycle to limit proliferation using cell biology, biochemistry and biophysical techniques. They are also interested in chemical biology approaches to modulate clock timing with structurally informed in vitro and cell-based screening platforms. [More]

Partch Publications Carrie Partch's E-Mail

Prof RubinMolecular Mechanisms of Cell Cycle Regulation and Cancer

Seth Rubin, Chemistry and Biochemistry

The Rubin laboratory uses a variety of structural and biochemical techniques to investigate the molecular mechanisms that control the eukaryotic cell cycle. The aim is to elucidate detailed molecular pictures of protein-protein interactions and how these interactions are regulated by structural and chemical modifications. Improper regulation of these protein interaction networks is commonly associated with aberrant cell proliferation and cancer. [More]

Rubin Publications Seth Rubin's E-Mail

Prof Josh StuartComputational Functional Genomics

Josh Stuart, Dept. of Biomolecular Engineering

Josh Stuart's background is in machine-learning applied to high-throughput datasets and an expertise in developing computational models to integrate multiple sources of molecular biology information. His research focuses on discovering how gene networks program cellular responses and search engines to scan large collections of high-throughput results to predict how genes function. His labrecently developed the PARADIGM pathway-based models to integrate multiple sources of gene activity to predict alterations and clinical outcomes in tumor samples to decipher pathway alterations in many cancer cohorts. Stuart co-leads a Genome Data Analysis Center for the TCGA project, co-chairs the pan-cancer TCGA effort, is a member of the bioinformatics pathway’s group for the International Cancer Genome Consortium, and directs the computational pathway analysis for a Stand Up To Cancer Dream Team to identify therapies for resistant prostate cancer. [More]

Stuart Publications Josh Stuart's Email

Prof Christopher VollmersDNA Sequencing Tools for the Analysis of B cells

Christopher Vollmers, Dept. of Biomolecular Engineering

Our adaptive immune systems is highly efficient in protecting us from the most diverse intruders. B cells are an essential part of the adaptive immune system. Each B cell uniquely rearranges its genome several times to produce an unique antibody. Until very recently, the analysis of B cell populations circulating in the periphery at any given time was labor intensive and low throughput. The Vollmers lab focuses on developing DNA sequencing tools to analyze B cells on a population and single cell level. [More]

Vollmers' Publications Christopher Vollmers' E-Mail

Prof Fitnat YildizEx-vivo Survival Mechanisms Used by Vibrio cholerae between Epidemics

Fitnat Yildiz, Dept. of Microbiology and Environmental Toxicology

Ex-vivo Survival Mechanisms used by Vibrio cholerae between Epidemics: Fitnat Yildiz's laboratory investigates signaling and regulatory networks of Vibrio cholerae, the causative agent of the Asiatic cholera. She and her colleagues are particularly interested in those mechanisms that allow the pathogen to adapt to changes in its habitat. The bacteria's ability to survive in different growth modes in aquatic environments is closely linked to seasonal epidemics of cholera. Yildiz's laboratory is attempting to identify and characterize genes and processes associated with phase variations of the pathogen. Their results will be useful for prediction and control of epidemics of this devastating disease. [More]

Yildiz Publications Fitnat Yildiz's E-Mail

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