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CHEMICAL BIOLOGY
 
 

• Phil Crews (Chem) Marine Natural Products as Potent Agents Against Human Disease
• Ted Holman (Chem) Lipoxygenase Inhibitors as Potential Anti-Inflammatory Drugs
• Scott Lokey (Chem) A Small Molecule Approach for Studying Signaling Pathways Related to Cell Motility and Cancer
• Carrie Partch (Chem) Exploring the Molecular Basis for Circadian Timekeeping in Mammals
• Jevgenij Raskatov (Chem) Disease-Oriented Chemical Biology
• Nik Sgourakis (Chem) Modelling the Structures of Protein Complexes from Sparse Experimental Data
• Bill Sullivan (MCD) Wolbachia host cell cycle/ cytoskeletal interactions in insects and filarial nematodes

Prof Phil CrewsMarine Natural Products as Potent Agents Against Human Disease

Phil Crews, Dept. of Chemistry and Biochemistry

A primary goal of Phillip Crews' marine natural products research is to understand the chemistry of tropical marine sponges. Using bioassay-guided isolation assists us in the discovery of natural products potent against human diseases, such as cancer or viruses. Their search for novel active compounds incorporates elements of structure elucidation, but there are other dimensions to this research, including questions in the areas of chemical ecology, marine natural products biosynthesis, and the relationship between secondary metabolite chemistry and taxonomy... [More]

Crews' Publications Phil Crews' E-Mail

Prof HolmanLipoxygenase Inhibitors as Potential Anti-Inflammatory Drugs

Ted Holman, Dept. of Chemistry & Biochemistry

Lipoxygenases are enzymes implicated in a broad range of inflammatory diseases, such as diabetes, heart disease, and stroke, to name a few. Ted Holman's laboratory examines the enzymatic mechanism and biological function of lipoxygenase in the hopes of understanding how the enzyme functions and developing novel inhibitors. In collaboration with medical school collaborators, his laboratory has identified potent lipoxygenase inhibitors and are currently characterizing their structure/function reactivity. The results of this work will shed light on their potential as anti-inflammatory agents. [More]

Holman's Publications Ted Holman's E-Mail

Prof Scott LokeyA Small Molecule Approach for Studying Signaling Pathways Related to Cell Motility and Cancer

Scott Lokey, Chemistry and Biochemistry

The laboratory of Scott Lokey uses a small molecule approach, called chemical genetics, to study signaling pathways related to cell cycle checkpoints and the actin cytoskeleton. In one study, Lokey and his co-workers are developing screens of natural compounds that can be used to examine how cells detect their own DNA damage. Studies such as these might lead to development of a new class of chemotherapeutic agents. [More]

Lokey Publications Lokey's E-Mail

Prof Rubin Exploring the Molecular Basis for Circadian Timekeeping in Mammals

Carrie Partch , Chemistry and Biochemistry

Mammalian physiology is synchronized into 24-hour rhythms that coincide with the solar day by an intrinsic molecular clock. As a global regulator of homeostasis, disruption of the circadian clock has profound consequences on human health, leading to depression, metabolic syndromes, cancer, and premature aging. The Partch lab studies how the 24-hour periodicity of this molecular clock is generated and how it integrates with the cell cycle to limit proliferation using cell biology, biochemistry and biophysical techniques. They are also interested in chemical biology approaches to modulate clock timing with structurally informed in vitro and cell-based screening platforms. [More]

Partch Publications Carrie Partch's E-Mail


Prof. Jevgenij A. RaskatovDisease-Oriented Chemical Biology

Jevgenij A. Raskatov, Dept. of Chemistry and Biochemistry

Raskatov draws inspiration from aging-related medicinally challenging questions, which are becoming increasingly pressing as life expectancy continues to rise (the cancer/inflammation interface is of specific interest). Raskatov's lab identifies biomolecular signaling nodes that are sufficiently well-understood at the molecular level, so that a biology problem can be translated into a chemistry problem. As chemists, their goal is to synthesize molecules and study their properties by means of NMR spectroscopy (1), crystallography (2) and DFT computation (3). Molecular scaffolds that show initial promise are tested in relevant biological systems both in cell culture (4) and in vivo (5). [More]

Jevgenij Raskatov's Publications Jevgenij Raskatov's Email

Prof Nik SgourakisModelling the Structures of Protein Complexes from Sparse Experimental Data

Nik Sgourakis, Dept. of Chemistry and Biochemistry

Research in the Sgourakis lab focuses on elucidating the structures of important protein complexes involved in Immune recognition of viruses, bacterial secretion and neurodegeneration. Determining the structural basis of protein-protein interactions and self-assembly will help clarify fundamental biological mechanisms and facilitate the design of novel therapeutics. To achieve this, structure-based modelling at sufficient resolution is required. The Sgourakis lab is developing and implementing new tools based on Nuclear Magnetic Resonance spectroscopy and complementary sources of experimental data alongside advanced computational sampling methods. The integration of a range of experimental and computational approaches enables structural studies of proteins and their complexes at high resolution. [More]
Sgourakis Publications Nik Sgourakis' Email

Prof Bill SullivanWolbachia Host Cell Cycle/Cytoskeletal Interactions in Insects and Filarial Nematodes

Bill Sullivan, Dept. of MCD Biology

Among bacterial endosymbionts, the interaction between Wolbachia and their insect hosts is one of the most successful. Wolbachia are gram-negative, obligate, intracellular bacteria, carried by millions of arthropod and nematode hosts worldwide. It was recently discovered that Wolbachia maintain an obligate symbiotic relationship with pathogenic nematodes and are the causative agent of Elephantiasis and African River-blindness, neglected diseases afflicting over 200 million globally. The Sullivan lab uses a combination of molecular genetic, cellular and biochemical approaches to define the mechanisms by which Wolbachia interacts with the host cytoskeleton and influences the host cell cycle. In addition, they are engaged in high-throughput cell-based screens, using automated microscpy to identify new potent anti-Wolbachia compounds for combating Elephantiasis and River-blindness. [More]

Sullivan's Publications Bill Sullivan's E-Mail
 

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