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 Computational Functional Genomics
Josh Stuart, Dept. of Biomolecular Engineering
Josh Stuart's research group develops computational approaches for predicting gene function and discovering how gene activity is regulated and modulated in response to cellular events and processes. Their methods combine genome-wide functional data across multiple organisms to identify conserved genetic mechanisms. The group has three broad aims: 1) to develop computational models to predict gene function, 2) to integrate datasets across multiple organisms to identify core molecular pathways, and 3) to develop algorithms and resources for biological discovery. Stuart also collaborates with numerous colleagues at UCSC and elsewhere to predict molecular targets of drugs, causal networks in disease, and pathways involved in stem cell differentiation. [More]
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 Marine Natural Products as Anti-Cancer Compounds
Phil Crews, Dept. of Chemistry and Biochemistry
The Crews laboratory investigates the chemical structure and biological activity of chemical compounds that are derived from marine organisms. Among its many research projects, the laboratory collaborates with scientists at other research institutions and pharmaceutical industries to explore the identification and development of naturally occuring compunds in the fight against cancer. [More]
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 Lipooxygenase Inhibitors as Potential Anti-Cancer Drugs
Ted Holman, Dept. of Chemistry & Biochemistry
Lipoxygenases are enzymes implicated in a broad range of human cancers, as well as cardiac and inflammatory diseases. Ted Holman's laboratory examines the enzymatic mechanism and biological function of lipoxygenase in the hopes of developing novel inhibitors. In collaboration with UCSC Professor Phil Crews, his laboratory has identified potent lipoxygenase inhibitors and are currently characterizing their structure/function reactivity. The results of this work will shed light on their potential as anti-cancer agents. [More]
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 Drugs from the Sea: Marine Natural Products as Chemical Probes
Roger Linington, Dept. of Chemistry and Biochemistry
Dr. Linington’s natural products and organic chemistry lab focuses on two complimentary areas of neglected infectious disease research: identification of novel drug leads against malaria and cholera, and development of natural products as chemical probes to explore questions of basic biochemistry in the arena of parasitology. Natural products are a crucial component of todays therapeutic arsenal and exploration of the diversity present in microbes from marine sediments represents an exciting new avenue for contemporary drug discovery. [More]
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Chemical Genetics
Scott Lokey, Dept. of Chemistry and Biochemistry
The laboratory of Scott Lokey uses a small molecule approach, called chemical genetics, to study signaling pathways related to cell cycle checkpoints and the actin cytoskeleton. In one study, Lokey and his co-workers are developing screens of natural compounds that can be used to examine how cells detect their own DNA damage. Studies such as these might lead to development of a new class of chemotherapeutic agents. [More]
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| Lipooxygenase Inhibitors as Potential Anti-Cancer Drugs
Ted Holman, Dept. of Chemistry & Biochemistry
Lipoxygenases are enzymes implicated in a broad range of human cancers, as well as cardiac and inflammatory diseases. Ted Holman's laboratory examines the enzymatic mechanism and biological function of lipoxygenase in the hopes of developing novel inhibitors. In collaboration with UCSC Professor Phil Crews, his laboratory has identified potent lipoxygenase inhibitors and are currently characterizing their structure/function reactivity. The results of this work will shed light on their potential as anti-cancer agents. [More]
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 Natural and Man-made Therapies from the Laboratory
Joseph Konopelski, Chemistry and Biochemistry
Numerous drugs and reagents used in biomedical research originate from products derived from plant and animal life. In the laboratory of Joseph Konopelski, investigators synthesize variant forms of these molecules for biomedical research. Keywords: Organic Synthesis, Synthetic Methodology, Asymmetric Synthesis, Heterocycles, Bioorganic Chemistry, Protein Chemistry and Synthesis, Biochemistry. [More] |
 Ex-vivo Survival Mechanisms Used by Vibrio cholerae between Epidemics
Fitnat Yildiz, Dept. of Microbiology and Environmental Toxicology
Ex-vivo Survival Mechanisms used by Vibrio cholerae between Epidemics: Fitnat Yildiz's laboratory investigates signaling and regulatory networks of Vibrio cholerae, the causative agent of the Asiatic cholera. She and her colleagues are particularly interested in those mechanisms that allow the pathogen to adapt to changes in its habitat. The bacteria's ability to survive in different growth modes in aquatic environments is closely linked to seasonal epidemics of cholera. Yildiz's laboratory is attempting to identify and characterize genes and processes associated with phase variations of the pathogen. Their results will be useful for prediction and control of epidemics of this devastating disease. [More]
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