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 Genome Bioinformatics: Comparative Sequence Analysis of Mammalian Genomes
David Haussler, Dept. of Biomolecular Engineering
Dr. Haussler's research lies at the interface of mathematics, computer science, and molecular biology. He has focused on computational analysis and classification of DNA, RNA, and protein sequences. As a collaborator on the public Human Genome Project, his team posted the first publicly available computational assembly of the human genome sequence on the Internet, and it now maintains UCSC's Genome Browser, which is used extensively in biomedical research. [More]
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 Large Scale Approaches to Study Whole-Genome Biology
Todd Lowe, Dept. of Biomolecular Engineering
Todd Lowe's research group uses a mixture of computational and experimental genomics to identify and characterize non-coding RNA (ncRNA) genes and to study the unique biology of Archaeal “extremophiles” – microbes that live at the edge of the limits of life. His team has created several classes of non-coding RNAs gene-finders, and has created full-genome DNA microarrays for two different hyperthermophile species to study ancient forms of respiration and strategies for thermo-tolerance. The group has also created a genome browser and functional genomics resource for all archaeal and extremophile species (archaea.ucsc.edu), now funded by the NSF. [More]
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 Tools for Studying Genes and Proteins
Nader Pourmand, Dept. of Biomolucular Engineering
The Pourmand lab develops new tools and technologies that integrate biology, electronics, and nanofabrication for the detection and study of genes and proteins. These tools are specifically designed to increase the speed and lower the cost of sample analysis. The lab directs particular attention to the development of medically relevant technology, such as instruments for pathogen detection. Pourmand is also spearheading UCSC's effort to establish a new high-throughput, high-quality sequencing facility. [More]
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 RNA Splicing in Yeast and Humans
Manuel Ares, Jr., MCD Biology
The Ares laboratory investigates molecular mechanisms that control RNA splicing, a process that influences the nature of the protein expressed from a gene. Analysis of such mechanisms can help determine why the same disease gene produces variable symptoms in different individuals.
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 Regulation of Chromatin Structure and Gene Expression
John Tamkun, Dept. of MCD Biology
The Tamkun lab investigates regulation of chromatin's high order structure and its role in gene expression. Composed of DNA and proteins, chromatin's ability to fold enables the eukaryotic genome to be packaged into an extremely small space inside the nucleus of the cell. Proper transcription and replication of the genome also depend upon precise regulation of these dynamic structures, with defects in these processes believed to underly many human diseases. [More]
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 Regulation of Pre-mRNA Splicing and Post-Transcriptional Regulation by Micro RNAs
Alan Zahler, MCD Biology
The human genome carries the blueprint for the creation of proteins, the molecular machines that carry out most of the work in the body. However, the diversity of the pool of available proteins is greatly enhanced by alterative splicing of our genes. The Zahler laboratory examines the nematode Caenorhabditis elegans in order to understand the regulatory mechanisms of this alternative splicing.. [More]
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 Ex-vivo Survival Mechanisms Used by Vibrio cholerae between Epidemics
Fitnat Yildiz, Dept. of Microbiology and Environmental Toxicology
Ex-vivo Survival Mechanisms used by Vibrio cholerae between Epidemics: Fitnat Yildiz's laboratory investigates signaling and regulatory networks of Vibrio cholerae, the causative agent of the Asiatic cholera. She and her colleagues are particularly interested in those mechanisms that allow the pathogen to adapt to changes in its habitat. The bacteria's ability to survive in different growth modes in aquatic environments is closely linked to seasonal epidemics of cholera. Yildiz's laboratory is attempting to identify and characterize genes and processes associated with phase variations of the pathogen. Their results will be useful for prediction and control of epidemics of this devastating disease. [More]
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