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CHEMICAL BIOLOGY
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 Marine Natural Products as Anti-Cancer Compounds
Phil Crews, Dept. of Chemistry and Biochemistry
The Crews laboratory investigates the chemical structure and biological activity of chemical compounds that are derived from marine organisms. Among its many research projects, the laboratory collaborates with scientists at other research institutions and pharmaceutical industries to explore the identification and development of naturally occuring compunds in the fight against cancer. [More]
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 Lipoxygenase
Inhibitors as Potential Anti-Cancer Drugs
Ted Holman, Dept. of Chemistry & Biochemistry
Lipoxygenases are enzymes implicated in a broad range
of human cancers, as well as cardiac and inflammatory diseases. Ted Holman's
laboratory examines the enzymatic mechanism and biological function of lipoxygenase
in the hopes of developing novel inhibitors. In collaboration with UCSC Professor
Phil Crews, his laboratory has identified potent lipoxygenase inhibitors and
are currently characterizing their structure/function reactivity. The results
of this work will shed light on their potential as anti-cancer agents. [More]
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 Drugs
from the Sea: Marine Natural Products as Chemical Probes
Roger Linington, Dept. of Chemistry and Biochemistry
Dr. Linington’s natural products and organic chemistry
lab focuses on two complimentary areas of neglected infectious disease research:
identification of novel drug leads against malaria and cholera, and development
of natural products as chemical probes to explore questions of basic biochemistry
in the arena of parasitology. Natural products are a crucial component of todays
therapeutic arsenal and exploration of the diversity present in microbes from
marine sediments represents an exciting new avenue for contemporary drug discovery.
[More] |
 A
Small Molecule Approach for Studying Signaling Pathways Related to Cell Motility
and Cancer
Scott Lokey, Chemistry and Biochemistry
The laboratory of Scott Lokey uses
a small molecule approach, called chemical genetics, to study signaling pathways
related to cell cycle checkpoints and the actin cytoskeleton. In one study,
Lokey and his co-workers are developing screens of natural compounds that can
be used to examine how cells detect their own DNA damage. Studies such as these
might lead to development of a new class of chemotherapeutic agents. [More]
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 Cell
Cycle, Cytoskeleton and Pathogenesis
Bill Sullivan, Dept. of MCD Biology
The Sullivan lab uses the Drosophila embryo
as a model system to investigate the mechanisms that drive furrow invagination
during cytokinesis. Through a combination of cellular and molecular genetic
approaches, the Sullivan group has showed that furrow formation requires coordinated
cell cycle regulated and endocytic-based vesicle recruitment. These studies
have also identified a new role for cell cycle checkpoints in coordinating the
nuclear cycle with cytokinesis. More recently, the lab has applied these approaches
toward understanding the mechanisms by which the widespread intracellular insect
pathogen, Wolbachia, influences host nuclear and cytoplasmic cell cycles.
[More]
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