UCSC Chemical Screening Equipment

Chemical Screening Facility

Confocal Microscopy Facility

Electron Microscopy and Digital Imaging Facility

Electron Spin Resonance Facility

Microarray Facility

Macromolecular X-ray Crystallography Facility

Mass Spectrometry Facility

Nanosecond Time-resolved Laser Spectroscopy Laboratories

Nuclear Magnetic Resonance Facility

Proteomics Facility

UCSC Chemical Screening Center Current Equipment

The Chemical Screening Center is available for researchers to perform high-throughput screens (HTS) to search for biologically active compounds and siRNA targeted toward a variety of biological systems. The Center houses liquid handling robotics, detectors, imaging equipment, and compound libraries. To reserve screening time at the facility, please contact Lily Shiue.

Liquid Handling Robotics Perkin Elmer Janus MDT	This robotic liquid handler performs X-Y-Z robotic functions using a head equipped with a 96-channel pipette for reformatting libraries and high throughput compound addition. It also has a 384-pin tool capable of delivering 100 nL volume transfers to multi-well plates (either 384 or 1536).
Liquid Handling Robotics Perkin Elmer Janus Varispan	This is an X-Y-Z robotic liquid handler capable with an independently controllable 8-tip pipet, used for performing serial dilutions, compound cherry picking, and any other routine automated liquid handling task.
Liquid Handling Robotics BioTek plate washer	This plate washer is capable of aspirating liquids from 384- and 96-well plates, with plate stacker for walk-away HT applications.
Liquid Handling Robotics Matrix WellMate	Automated peristaltic dispenser with plate stacker. Digitally operated, rapidly dispenses reagents/buffers into 384- and 96-well plates.
Detectors Perkin-Elmer EnVision	Fast, state-of-the-art plate reader with plate stacker. Has absorption, fluorescence, ultrasensitive luminescence, and fluorescence polarization modes.
Imaging Molecular Devices ImageExpress	An automated microscope for high content screening. Nikon objectives, up to 60x, with bright fiber optic light source, robotic stage that accommodates multi-well plates and slides, and image analysis software.
Compound Libraries	55,000 commercial collection from ChemDiv, and a growing collection of marine natural products from the Phil Crews and Roger Linington research groups at UCSC.

The Chemical Screening Center is funded by grants from the National Institutes of Health, the U.S. Department of State, and the California Institute for Quantitative Biomedical Research.