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 Methylating Agents and the Treatment of Cancer
Manel Camps, Department of Environmental Toxicology
Spontaneous DNA Methylation results from methyl donors reacting with DNA. DNA methylation is a potent carcinogen. Paradoxically, in addition to being carcinogenic, methylating agents are also mainstays for cancer treatment. Among his research interests, Dr. Camps examines the molecular mechanisms of methylating agent toxicity to design safer and more effective strategies for cancer chemotherapy.
(Keywords: DNA methylation, bone marrow toxicity, chemotherapy, temozolomide, gene therapy, carcinogenesis, chemoprotection, AlkB, oxidative demethylases, ABH2, directed enzyme evolution, mutagenesis, MMS, MNNG)
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