Manel Camps, Microbiology and Environmental Toxicology

The Camps laboratory uses molecular genetic and computational approaches to study  the biological consequences of random changes in genetic information  (mutations) that occur spontaneously  or as a result of environmental insults. They couple the generation of random mutant libraries with specific selections or screens  to study the functional impact of point mutations and to establish how genes evolve in response to selective pressure. This work is relevant for the identification of risk factors of disease, for understanding the origins of drug resistance, and for engineering biological activities. The Camps laboratory also use induction of random genetic alterations (mutagenesis) as an indicator of DNA damage for high-throughput analysis of chemical libraries. Through this approach, the Camps laboratory aims at exploiting the particular susceptibility of rapidly replicating cells to DNA damage for therapeutic purposes with the hopes of identifying candidates that complement or enhance existing anti-tumor therapies. (Keywords: DNA methylation, bone marrow toxicity, chemotherapy, gene therapy, carcinogenesis, chemoprotection, oxidative demethylases, directed enzyme evolution, mutagenesis)

Camps Laboratory Research

Camps Publications

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