Meiotic Chromosome Dynamics Needhi Bhalla, Department of MCD Biology During meiosis, homologous chromosomes must pair, synapse and recombine with their unique partner; all of these events are required for accurate chromosome segregation. The Bhalla lab uses C. elegans as a model system to dissect how these events are regulated, coordinated and monitored to produce gametes, such as sperm and eggs, with the correct chromosome complement. Defects in meiotic chromosome segregation usually lead to embryonic inviability but can result in developmental disorders, infertility or cancer predisposition.cell biology and chromosome biology